1.基本信息

王乐，博士，副教授，硕士生导师。2007年毕业于西北老员工命科学与技术基地班，获理学学士学位；2010年毕业于西北大学细胞生物学专业，获理学硕士学位；2015年毕业于西安交通老员工物医学工程专业，获工学博士学位；2015年6月进入伟德化学化工公司工作至今。现主要从事天然药物治疗重大疾病分子机制分析、计算机辅助药物设计等方向交叉研究。近年来发表SCI论文20余篇，主持国家自然科学基金青年项目、陕西省科技厅重点研发计划项目等课题10余项，获批专利、软件著作权10余件。担任Food & Medicine Homology等期刊青年编委。曾获宝鸡市青年科技新星、伟德年度科研人物等荣誉。

2.研究方向

（1）天然药物活性成分与药理机制分析

（2）有机质谱分析

（3）人工智能与分子模拟

3.开设课程

承担了《现代仪器分析》《人工智能在分析化学中的应用》等课程。

4.主持科研项目

（1）国家自然科学基金青年项目(82104682)，深度学习联合多组学方法探究甘露消毒丹通过肺—肠轴调节免疫失衡保护肺损伤的分子机制。

（2）陕西省科技厅重点研发计划(2022SF-208)，深度学习联合多尺度分子模拟方法智能解析“肺肠同治”方剂中保护肺损伤的免疫活性成分群及其“既病防变”机制。

（3）陕西省自然科学基金青年项目(2018JQ2064)，男性青年原发性高血压患者血清生物标记物的筛选研究。

（4）陕西省教育厅重点实验室项目(16JS008)，基于LC-MS的秦岭草药太白三七活性成分筛选与作用机制研究。

（5）宝鸡市科技计划重点产业链项目(2026-ZDCYL-005), 机器学习联合多维组学探究黄连素调节免疫微环境抑制颈动脉粥样硬化的机制

（6）宝鸡市哲学社会科学年度课题(BJSKND-202632), 深度学习赋能宝鸡道地药材产业链数智化升级路径研究。

5. 发表论文

(1) Nana Tan, Jia Lu, Zhuanghong Li, Shiping Zhang, Huan Wang, Jingbo Hu, Tian Wang, Jian Xiao, Xiaoling Wang, Le Wang*. A systematic insight into glycycoumarin as potential IL-8/topo I inhibitor from natural products collected in Taibai mountain based on the combination of in silico and bioassay. Journal of Computer-Aided Molecular Design, 2025, 39.1: 28.

(2) Tian Wang, Nana Tan, Jia Lu, Zhuanghong Li, Huan Wang, Jingbo Hu, Shiping Zhang, Jianzhao Qi, Xiaoling Wang, Le Wang*, Systematic analysis of natural topoisomerase inhibitors from Forsythiae Fructus by ultrafiltration-UPLC-ESI-MS/MS, pharmacophore modelling, and molecular dynamics simulation, Natural Product Research, 2024, 2425055.

(8) Tong Chen, Jingbo Hu, Huan Wang, Nana Tan, Jianzhao Qi, Xiaoling Wang, Le Wang*, Combination of bioaffinity ultrafiltration-UFLC-ESI-Q/TOF-MS/MS, in silico docking and multiple complex networks to explore antitumor mechanism of topoisomerase I inhibitors from Artemisiae Scopariae Herba, BMC Complementary Medicine and Therapies, 2023, 23:317.

(4) Nana Tan, Jingbo Hu, Huan Wang, Tong Chen, Dongzhu Duan, Jianzhao Qi, Xiaoling Wang, Le Wang*, Integrated analysis of topoisomerase I inhibitors from flavonoids of Scutellaria baicalensis Georgi using bioaffinity ultrafiltration UPLC-TripleTOF MS/MS, molecular docking and target-based multiple complex networks [J]. Fitoterapia, 2023, 168.  

(5) Le Wang*, Wenbo Diwu, Nana Tan, Huan Wang, Jingbo Hu, Bailu Xu, Xiaoling Wang*, A Pathway-based Protein-Protein Association Network to Explore Mechanism of α-Glucosidase Inhibitors from Scutellaria baicalensis Georgi against Type 2 Diabetes, IET Systems Biology, 2021, 15 (2).

(6) Le Wang*, Nana Tan, Huan Wang, Jingbo Hu, Wenbo Diwu, Xiaoling Wang*, A systematic analysis of natural α-glucosidase inhibitors from flavonoids of Radix scutellariae using ultrafiltration UPLC-TripleTOF-MS/MS and network pharmacology, BMC Complementary Medicine and Therapies, 2020, 10 (172): 1-17.

(7) Le Wang, Fuhong Cheng, Jingbo Hu, Huan Wang, Nana Tan, Shaokang Li, Xiaoling Wang*, Pathway-based gene-gene interaction network modelling to predict potential biomarkers of essential hypertension. Biosystems, 2018, 10 (172): 18-25.

(8) Le Wang, Nana Tan, Jiayao Hu, Huan Wang, Dongzhu Duan, Lin Ma, Jian Xiao, Xiaoling Wang*, Analysis of the main active ingredients and bioactivities of essential oil from Osmanthus fragrans Var. thunbergii using a complex network approach, BMC systems biology, 2017, 11 (1): 144.

(9) Le Wang, Entai Hou, Lijun Wang, Yanjun Wang, Lingjian Yang, Xiaohui Zheng, Guangqi Xie, Mingyu Liang, Zhongmin Tian*, Reconstruction and analysis of correlation networks based on GC-MS metabolomics data for young hypertensive men, Analytica Chimica Acta, 2015, 854: 95-105.(10) Le Wang, Entai Hou, Zhengjun Wang, Na Sun, Liqing He, Lan Chen, Mingyu Liang, Zhongmin Tian*, Analysis of metabolites in plasma reveals distinct metabolic features between Dahl salt-sensitive rats and consomic SS. 13BN rats, Biochemical and Biophysical Research Communications, 2014, 450(1): 863-869.

6. 联系方式

通讯地址：陕西省宝鸡市渭滨区高新大道1号宝鸡文理学院明理楼

邮编：721013

E-mail: leolynne@gmail.com